In experiments on CBA mice, we studied the effects of the inhibitors of cyclooxygenase and lipoxygenase pathways of the metabolism of arachidonic acid (indomethacin and nordihydroguaiaretic acid, respectively) on the formation of antigeninduced suppressor cells and concomitant processes of lipid peroxidation and the monooxygenase system activity in spleen of mice following a tolerogenic dose of sheep red blood cells. It has been shown that nordihydroguaiaretic acid injection inhibited the formation of lymphocyte suppressors more significantly than indomethacin did, and it was followed with an activation of the monooxygenase system and a decrease of the lipid peroxidation intensity in spleen at the stage of the induction of cells-suppressors.

• Мартинова Тетяна Василівна (біологічні науки)

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