The aim of this study was to find the method to increase the immune system efficiency in the antitumor defence of organism. Ascite strains of Ehrlich's carcinoma and sarcoma 37 were used. The immunization of newborn mice has been estimated to be much more efficient than that of adult animals. The transplantation threshold of ascite tumors in adult animals after their immunization in the postnatal period increases 100 - 400 times as compared with control mice. The immunization of mice in the postnatal period essentially influences the chemical cancerogenesis induced by 20-methylcholantrene. Tumor appearance was decreased (50 % from control), and the induction period was increased. The usual immunization of adult animals was inefficient in this case. Thus, the immunization of animals in the postnatal period is more efficient than that of adult individuals and may be one of the ways to increase the antitumor resistance of organism.

• Казьмін Сергій Дмитрович (1934–2006) (біологічні науки)
• Тодор Ігор Миколайович (медичні науки)
• Чехун Василь Федорович (1956–) (медичні науки)

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