Aim - long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells under RF-EMR exposure were previously reported. Our study aims to assess a production of initial free radical species, which lead to oxidative stress in the cell. Embryos of Japanese quails were exposed in ova to extremely low intensity RF-EMR of GSM 900 MHz (0,25 mu W/cm²) during 158 - 360 h discontinuously (48 c - ON, 12 c - OFF) before and in the initial stages of development. The levels of superoxide (O₂^-), nitrogen oxide (NO^-), thiobaibituric acid reactive substances (TBARS), 8-oxo-2'-deoxyguanosine (8-oxo-dG) and antioxidant enzymes' activities were assessed in cells/tissues of 38-h, 5- and 10-day RF-EMR exposed and unexposed embryos. The exposure resulted in a significant persistent overproduction of superoxide and nitrogen oxide in embryo cells during all period of analyses. As a result, significantly increased levels of TBARS and 8-oxo-dG followed by significantly decreased levels of superoxide dlsmutase and catalase activities were developed in the exposed embryo cells. Conclusion: exposure of developing quail embryos to extremely low intensity RF-EMR of GSM 900 MHz during at least one hundred and fifty-eight hours leads to a significant overproduction of free radicals/reactive oxygen species and oxidative damage of DNA in embryo cells. These oxidative changes may lead to pathologies up to oncogenic transformation of cells.

• Бурлака Анатолій Павлович (1950–) (біологічні науки)
• Цибулін Олександр Сергійович (біологічні науки)
• Якименко Ігор Зіновійович (технічні науки)
• Якименко Ігор Леонідович (біологічні науки)

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