The objective of the research was to contribute to the continual search for natural products that could mitigate alterations in haematotogical indices due to cadmium poisoning. Seventy-two male Wistar rats were mobilized and divided into six groups (A - F). Group A served as the control one which was neither exposed to cadmium nor treated with palm oil traction. Group B was not treated with palm oil fractions but received a single dose of 20 mgkg<^>-1 body weight of cadmium chloride solution on the 29<^>th day of the experiment, while Groups C - E received 5 mlKg<^>-1 bodyweight of crude palm oil, silica gel extract, bleached extract and unsaponifiable extract of palm oil respectively for 28 days before a single dose of 20 mgKg<^>-1 body weight of cadmium chloride on the 29<^>th* day. Blood samples were collected from four animals via cardiac puncture on die 29<^>th, 30<^>th and 31<^>st day within intervals of 12 h, 24 h and 48 h after cadmium administration. This was then analysed for haematotogical parameters using an automated haematotogical analyser. Data analysis was carried out using the one-way factor analysis of variance at a significant level of p << 0,05. The impact of cadmium intoxication on haematotogical indices in rats was time-dependent and was mostly felt at the end of the 48-hour period indicating a significant decrease in the packed cell volume, haemoglobin and white blood cells values, while the increase due to cadmium was observed in mean corpuscular haemoglobin and mean cotpuscular volume values; pre-treatment of palm oil fractions mitigated the noxious effects of cadmium significantly near control values. Conclusions: crude palm oil and its fractions have the ability to mobilize antioxidant defence potentials against cadmium damage to blood cells.

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