Aryayev M. Adverse events of replacement therapy in children with growth hormone deficiency = Небажані явища замісної терапії в дітей із дефіцитом гормону росту / M. Aryayev, L. Senkivska // Здоров'я дитини. - 2023. - 18, № 4. - С. 267-270. - Бібліогр.: 14 назв. - англ.The purpose was to analyze and summarize the accumulated short-term and long-term safety data in children with growth hormone deficiency (GHD) treated using recombіnant human growth hormone (rhGH) based on the results of a physical examination, assessment of vital signs, laboratory parameters, and follow-up. The study was conducted at the Odesa Regional Children's Clinical Hospital from 2012 to 2022, with 92 children treated for GHD using rhGH at an average dose of 0,033 mg/kg/day. The evaluation of the safety of this therapy was based on assessing the incidence of adverse events (AEs) as a negative consequence of medical care. We analyzed both short-term and long-term outcomes. Conclusions: in general, in the short-term context, rhGH therapy for children with GHD is safe. The pain at the injection site is a clinically significant AE as a cognitive emotional barrier to the adherence to rhGH therapy. From the point of view of the long-term safety of rhGH therapy, the fact that type 2 diabetes was detected in 3 (3,26 %) children with increased body weight and obesity is essential.
Шифр НБУВ: Ж25721 Пошук видання у каталогах НБУВ
![](/irbis_nbuv/images/info.png) Якщо, ви не знайшли інформацію про автора(ів) публікації, маєте бажання виправити або відобразити більш докладну інформацію про науковців України запрошуємо заповнити "Анкету науковця"
|